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Lesinurad was developed as an add-on treatment for patients in whom serum UA target ranges weren't achieved with allopurinol alone.
Hypersensitivity reactions to allopurinol, a drug
commonly used within the treatment of hyperuricemia, are being reported with
rising frequency. A really serious allergic reaction to this drug is uncommon. The mechanism of the hypersensitivity reaction isn't
clear, but it could signify an immune complex illness extended by the persistence of a at the moment undefined
antigen. Mixture therapy with lesinurad and allopurinol may represent a remedy
possibility for patients with gout in whom goal levels of serum UA can't be achieved with a xanthine oxidase inhibitor alone and additional therapy is
warranted. In conclusion, lesinurad is a novel selective uric acid reabsorption inhibitor for the remedy of gout in combination with xanthine oxidase inhibitors.
We studied the efficacy of allopurinol, a xanthine oxidase inhibitor and free radical scavenger,
in decreasing posthypoxic-ischemic harm within the developing
mind of 7-d-old rat pups. kopa furosemide |
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